Melanized nigral neuronal numbers in Nigerian and British individuals
Identifieur interne : 003346 ( Main/Exploration ); précédent : 003345; suivant : 003347Melanized nigral neuronal numbers in Nigerian and British individuals
Auteurs : Uday B. Muthane [Inde] ; Yasha T. Chickabasaviah [Inde] ; Jasmine Henderson [Australie] ; Ann E. Kingsbury [Royaume-Uni] ; Linda Kilford [Royaume-Uni] ; Susarla K. Shankar [Inde] ; D. K. Subbakrishna [Inde] ; Andrew Lees (neurologue) [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-08.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Nigeria.
English descriptors
- KwdEn :
- Cell Count, Great Britain, Humans, Locus niger, Melanins (metabolism), Nervous system diseases, Neurons (cytology), Neurons (metabolism), Nigeria, Parkinson Disease (metabolism), Parkinson Disease (pathology), Reference Values, Substantia Nigra (cytology), Substantia Nigra (metabolism), alpha-Synuclein (metabolism), ethnicity, etiopathogenesis, neuromelanin, neuronal counts, substantia nigra.
- MESH :
- chemical , metabolism : Melanins, alpha-Synuclein.
- geographic : Great Britain, Nigeria.
- cytology : Neurons, Substantia Nigra.
- metabolism : Neurons, Parkinson Disease, Substantia Nigra.
- pathology : Parkinson Disease.
- Cell Count, Humans, Reference Values.
Abstract
The role of genetic and environmental factors in etiopathogenesis of Parkinson's disease (PD) is debated. The prevalence of PD is higher among white than nonwhite populations, yet it is five times higher in nonwhites living in the United States than in Nigeria. We compare counts of melanized nigral neurons between neurologically normal Nigerians and British brains. Neuronal counts were estimated in an age‐matched sample of 23 Nigerian and 7 British brains from neurologically normal individuals who had no Lewy bodies and Lewy neurites on α‐synuclein immunostaining. Two investigators blind to age and ethnicity performed counts of melanized neurons in a single 7‐μm hemisections showing the substantia nigra pars compacta. No significant difference exits in the number of neurons between the Nigerian and the British subjects (P = 0.1, NS). Differences in melanized nigral neuronal numbers may not explain differences in the prevalence of PD between white and nonwhite populations, suggesting factors other than neuronal numbers contribute to differential susceptibility of black vs. white races to PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20917
Affiliations:
- Australie, Inde, Royaume-Uni
- Angleterre, Grand Londres
- Londres
- National Hospital for Neurology and Neurosurgery
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002E97
- to stream Istex, to step Curation: 002E97
- to stream Istex, to step Checkpoint: 001E05
- to stream PubMed, to step Corpus: 002C61
- to stream PubMed, to step Curation: 002C61
- to stream PubMed, to step Checkpoint: 002C38
- to stream Ncbi, to step Merge: 001673
- to stream Ncbi, to step Curation: 001673
- to stream Ncbi, to step Checkpoint: 001673
- to stream Main, to step Merge: 004659
- to stream PascalFrancis, to step Corpus: 001A36
- to stream PascalFrancis, to step Curation: 001285
- to stream PascalFrancis, to step Checkpoint: 001A22
- to stream Main, to step Merge: 004B17
- to stream Main, to step Curation: 003346
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Melanized nigral neuronal numbers in Nigerian and British individuals</title><author><name sortKey="Muthane, Uday B" sort="Muthane, Uday B" uniqKey="Muthane U" first="Uday B." last="Muthane">Uday B. Muthane</name></author><author><name sortKey="Chickabasaviah, Yasha T" sort="Chickabasaviah, Yasha T" uniqKey="Chickabasaviah Y" first="Yasha T." last="Chickabasaviah">Yasha T. Chickabasaviah</name></author><author><name sortKey="Henderson, Jasmine" sort="Henderson, Jasmine" uniqKey="Henderson J" first="Jasmine" last="Henderson">Jasmine Henderson</name></author><author><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name></author><author><name sortKey="Kilford, Linda" sort="Kilford, Linda" uniqKey="Kilford L" first="Linda" last="Kilford">Linda Kilford</name></author><author><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K." last="Shankar">Susarla K. Shankar</name></author><author><name sortKey="Subbakrishna, D K" sort="Subbakrishna, D K" uniqKey="Subbakrishna D" first="D. K." last="Subbakrishna">D. K. Subbakrishna</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:33361C5AFC45B43269D8FACC0EE99FCF3CF3E8FB</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20917</idno><idno type="url">https://api.istex.fr/document/33361C5AFC45B43269D8FACC0EE99FCF3CF3E8FB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002E97</idno><idno type="wicri:Area/Istex/Curation">002E97</idno><idno type="wicri:Area/Istex/Checkpoint">001E05</idno><idno type="wicri:doubleKey">0885-3185:2006:Muthane U:melanized:nigral:neuronal</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16673400</idno><idno type="wicri:Area/PubMed/Corpus">002C61</idno><idno type="wicri:Area/PubMed/Curation">002C61</idno><idno type="wicri:Area/PubMed/Checkpoint">002C38</idno><idno type="wicri:Area/Ncbi/Merge">001673</idno><idno type="wicri:Area/Ncbi/Curation">001673</idno><idno type="wicri:Area/Ncbi/Checkpoint">001673</idno><idno type="wicri:doubleKey">0885-3185:2006:Muthane U:melanized:nigral:neuronal</idno><idno type="wicri:Area/Main/Merge">004659</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:06-0435102</idno><idno type="wicri:Area/PascalFrancis/Corpus">001A36</idno><idno type="wicri:Area/PascalFrancis/Curation">001285</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001A22</idno><idno type="wicri:doubleKey">0885-3185:2006:Muthane U:melanized:nigral:neuronal</idno><idno type="wicri:Area/Main/Merge">004B17</idno><idno type="wicri:Area/Main/Curation">003346</idno><idno type="wicri:Area/Main/Exploration">003346</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Melanized nigral neuronal numbers in Nigerian and British individuals</title><author><name sortKey="Muthane, Uday B" sort="Muthane, Uday B" uniqKey="Muthane U" first="Uday B." last="Muthane">Uday B. Muthane</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Chickabasaviah, Yasha T" sort="Chickabasaviah, Yasha T" uniqKey="Chickabasaviah Y" first="Yasha T." last="Chickabasaviah">Yasha T. Chickabasaviah</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Henderson, Jasmine" sort="Henderson, Jasmine" uniqKey="Henderson J" first="Jasmine" last="Henderson">Jasmine Henderson</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Prince of Wales Medical Research Institute, Randwick, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kilford, Linda" sort="Kilford, Linda" uniqKey="Kilford L" first="Linda" last="Kilford">Linda Kilford</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K." last="Shankar">Susarla K. Shankar</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Subbakrishna, D K" sort="Subbakrishna, D K" uniqKey="Subbakrishna D" first="D. K." last="Subbakrishna">D. K. Subbakrishna</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biostatistics, National Institute of Mental Health and Neurosciences, Bangalore</wicri:regionArea><wicri:noRegion>Bangalore</wicri:noRegion></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-08">2006-08</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1239">1239</biblScope><biblScope unit="page" to="1241">1241</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">33361C5AFC45B43269D8FACC0EE99FCF3CF3E8FB</idno><idno type="DOI">10.1002/mds.20917</idno><idno type="ArticleID">MDS20917</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Count</term><term>Great Britain</term><term>Humans</term><term>Locus niger</term><term>Melanins (metabolism)</term><term>Nervous system diseases</term><term>Neurons (cytology)</term><term>Neurons (metabolism)</term><term>Nigeria</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Reference Values</term><term>Substantia Nigra (cytology)</term><term>Substantia Nigra (metabolism)</term><term>alpha-Synuclein (metabolism)</term><term>ethnicity</term><term>etiopathogenesis</term><term>neuromelanin</term><term>neuronal counts</term><term>substantia nigra</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Melanins</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Great Britain</term><term>Nigeria</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neurons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Count</term><term>Humans</term><term>Reference Values</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Locus niger</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Nigeria</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of genetic and environmental factors in etiopathogenesis of Parkinson's disease (PD) is debated. The prevalence of PD is higher among white than nonwhite populations, yet it is five times higher in nonwhites living in the United States than in Nigeria. We compare counts of melanized nigral neurons between neurologically normal Nigerians and British brains. Neuronal counts were estimated in an age‐matched sample of 23 Nigerian and 7 British brains from neurologically normal individuals who had no Lewy bodies and Lewy neurites on α‐synuclein immunostaining. Two investigators blind to age and ethnicity performed counts of melanized neurons in a single 7‐μm hemisections showing the substantia nigra pars compacta. No significant difference exits in the number of neurons between the Nigerian and the British subjects (P = 0.1, NS). Differences in melanized nigral neuronal numbers may not explain differences in the prevalence of PD between white and nonwhite populations, suggesting factors other than neuronal numbers contribute to differential susceptibility of black vs. white races to PD. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li><li>Inde</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Inde"><noRegion><name sortKey="Muthane, Uday B" sort="Muthane, Uday B" uniqKey="Muthane U" first="Uday B." last="Muthane">Uday B. Muthane</name></noRegion><name sortKey="Chickabasaviah, Yasha T" sort="Chickabasaviah, Yasha T" uniqKey="Chickabasaviah Y" first="Yasha T." last="Chickabasaviah">Yasha T. Chickabasaviah</name><name sortKey="Shankar, Susarla K" sort="Shankar, Susarla K" uniqKey="Shankar S" first="Susarla K." last="Shankar">Susarla K. Shankar</name><name sortKey="Subbakrishna, D K" sort="Subbakrishna, D K" uniqKey="Subbakrishna D" first="D. K." last="Subbakrishna">D. K. Subbakrishna</name></country><country name="Australie"><noRegion><name sortKey="Henderson, Jasmine" sort="Henderson, Jasmine" uniqKey="Henderson J" first="Jasmine" last="Henderson">Jasmine Henderson</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name></region><name sortKey="Kilford, Linda" sort="Kilford, Linda" uniqKey="Kilford L" first="Linda" last="Kilford">Linda Kilford</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003346 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003346 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:33361C5AFC45B43269D8FACC0EE99FCF3CF3E8FB
|texte= Melanized nigral neuronal numbers in Nigerian and British individuals
}}
| This area was generated with Dilib version V0.6.23. |  |